Chronic lithium toxicity causes predominantly neurological symptoms. This can either be from reduced excretion, renal insufficiency, or dose adjustment (either by a clinician or by the patient). an increase in serum levels of lithium in a patient who is regularly taking lithium.Its efficacy in the treatment of psychiatric illnesses is thought to be due to the modulation of neurotransmitters, which has downstream effects through cell signaling and molecular mechanisms.” What is the clinical presentation of lithium toxicity?Ĭhronic toxicity = neurologic symptoms predominate “ In spite of long-term therapeutic use, the mechanism by which lithium acts is still not fully understood. Lithium largely has no effect when given in therapeutic doses to patients without mood disorders. Lithium was approved for the treatment of bipolar disorder in 1970, and it remains one of the most effective agents for both depressive and manic symptoms.
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